Wednesday, February 04, 2015

H2S: A Toxic Gas, and an Important Metabolic Neurotransmitter!

Hydrogen sulfide, in addition to being a poisonous gas associated with oil and gas wells, plays a huge number of critical metabolic and neurotransmitting roles in the human body.

Source.  Hydrogen sulfide-based therapeutics and gastrointestinal diseases: translating physiology to treatments
Melissa V. Chan , John L. WallaceAmerican Journal of Physiology - Gastrointestinal and Liver PhysiologyPublished 1 October 2013Vol. 305no. 7, G467-G473DOI: 10.1152/ajpgi.00169.2013


Source.  Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That BlossomedRui WangPhysiological ReviewsPublished 1 April 2012Vol. 92no. 2, 791-896DOI: 10.1152/physrev.00017.2011

Different signaling pathways in cardiovascular system modulated by H2S. AC, adenylyl cyclase; sGC, soluble guanylyl cyclase; PDEs, phosphodiesterases. The inhibitory effect is denoted with (−), and the stimulatory effect is denoted with (+).  Source: 

To research about a specific enzyme, the Human Metabolome Database HMDB works well.  To view maps of enzyme reactions, I recommend this interface:

No comments: